| abstract |
The present invention provides a method for preparing an optically active proton pump inhibitor compound, by adding a sulfide having a structure shown in formula (1) or a salt thereof in the presence of a chiral ligand having a structure shown in formula (3) , using iron salts, using hydrogen peroxide for oxidation to prepare optically active sulfoxides or their salts with a structure as shown in formula (2), which can produce high yield, high enantioselectivity, and safety. Low-cost preparation of high-purity optically active proton pump inhibitor compounds. A in the formula represents CH or N; R 1 represents a hydrogen atom, an alkyl group substituted by a halogen atom, or an alkoxy group substituted by a halogen atom; R 2 has 1 to 3, each independently representing an alkyl group, a dioxane amino group, or alkoxy group substituted by halogen atom or alkoxy group; R 3 independently represents hydrogen atom, halogen atom, cyano group, etc.; R 4 represents tertiary alkyl group; * and ** represent R-structure respectively type or S-configuration. |