| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_caacf483b6be9ae2d2677103a70559db |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-22 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 |
| filingDate |
2017-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9abff6519dd4ef7187a26e2eb8a2421
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46046a76b3091afddd097e41c3b8e313
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79b20292be67afd689c40a8e60e0505c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8827ff4277d55d116cefaab53a0bc58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf7cbb4430e361a9687365e0efdb1a41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_501a63205347ca57ab429d230b05213f |
| publicationDate |
2017-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-107417706-A |
| titleOfInvention |
Chlorin-artesunate conjugate with light and sound-sensitizing activity, preparation method and application thereof |
| abstract |
The invention relates to a class of chlorin artesunate conjugates with light and sound-sensitivity activities, a preparation method and application thereof, and belongs to the technical field of chemical medicine. The chlorin artesunate conjugate with light and sound-sensitizing activities of the present invention has different degrees of inhibitory effects on human liver cancer cell Hep G2 in the evaluation of anti-tumor activity in vitro. The photoactivity and ultrasound activity were higher than those of chlorin e6 and artesunate as positive controls respectively. It can be used for the preparation of photosensitizer and sound sensitizer in photodynamic therapy and sonodynamic therapy of tumor treatment. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111423446-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113788848-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111744014-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109432439-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020150831-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3914598-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113788848-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111423446-B |
| priorityDate |
2017-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |