http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107417598-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-6443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1029 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-57 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-57 |
| filingDate | 2017-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107417598-B |
| titleOfInvention | Fluorescent probe for detecting G-quadruplex DNAs (deoxyribonucleic acids) and preparation method thereof |
| abstract | The invention provides a fluorescent probe for detecting G-quadruplex DNAs (deoxyribonucleic acids), which is named as 3- (4-dimethylaminophenyl) -2- (N-methylpyridin-4-yl) acrylonitrile iodide salt. The preparation method comprises the following steps: (1) 4-pyridine acetonitrile hydrochloride reacts with triethylamine to prepare 4-pyridine acetonitrile; (2) 4-pyridine acetonitrile reacts with methyl iodide to obtain 4-pyridine acetonitrile methylated iodized salt; (3) 4-pyridine acetonitrile methylated iodized salt, 4-dimethylaminobenzaldehyde and potassium tert-butoxide react to obtain a target product 3- (4-dimethylamino phenyl) -2- (N-methylpyridine-4-yl) acrylonitrile iodized salt. The binding capacity of the prepared fluorescent probe and the G-quadruplex DNAs is far greater than that of the prepared fluorescent probe and the double-helix DNA, and the fluorescence intensity after the fluorescent probe and the G-quadruplex DNAs are combined is also obviously greater than that after the fluorescent probe and the double-helix DNA are combined, so that the fluorescent probe can be used for specific detection of the G-quadruplex DNAs. |
| priorityDate | 2017-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.