http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107412859-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-258 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2017-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107412859-B |
| titleOfInvention | Preparation method of double-gene time-sequence slow-release tissue engineering scaffold material |
| abstract | The invention discloses a preparation method of a double-gene time-sequence slow-release tissue engineering scaffold material, which comprises the steps of firstly encapsulating IGF-I-containing plasmid by using a slow-release material with larger molecular weight to prepare slow-release microspheres, and then using supercritical CO for the microspheres, P L GA with smaller molecular weight and BMP-2-containing plasmid 2 And a particle leaching method to prepare the three-dimensional porous tissue engineering material. When the material is implanted into a body, because the BMP-2 plasmid is not encapsulated by the sustained-release microspheres, the surrounding body material with smaller molecular weight is degraded firstly, and the BMP-2 plasmid is released firstly; the IGF-I plasmid is delayed to release due to the encapsulation of the material with larger molecular weight, and the effect of releasing two target genes in a certain sequence can be obtained. The material can simulate the physiological process of tissue repair to express cell factors in a time sequence, is more favorable for tissue regeneration, reduces the side effect of the whole body, can release gene products locally and continuously, and can increase the local treatment effect to the maximum extent. |
| priorityDate | 2017-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 129.