| abstract |
A kind of preparation method and application of the nanometer formulation of Legumain responses substep release adriamycin/curcumin sustained release, with the high expression Legumain of tumor tissues biological characteristics, the nanogel of Legumain responses is prepared, so as to realize the dual-target effect to tumor tissues（Active targeting and passive target）Reduce the secondary injury of adriamycin normal tissue, nanometer formulation prepared by the present invention can make medicine and inhibitor priority release function, into after cell, inhibitor first discharges from carrier, occupies drug-resistant protein avtive spot, then make insoluble drug release, it thus can at utmost reduce drug efflux, reverse multidrug resistance. |