| abstract |
Provided herein are methods, compounds and compositions for reducing ApoCIII mRNA and protein expression in patients with localized lipodystrophy. Also provided herein are methods, compounds and compositions for treating, preventing, delaying or ameliorating localized lipodystrophy in a patient. Also provided herein are methods, compounds and compositions useful for treating, preventing, delaying or ameliorating any one or more of pancreatitis, cardiovascular disease or metabolic disorders associated with localized lipodystrophy or symptoms thereof in a patient. |