http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107382820-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-46 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-46 |
| filingDate | 2017-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107382820-B |
| titleOfInvention | Synthetic method of 3-aryl isoindole derivative |
| abstract | The invention relates to a synthesis process of a 3-aryl isoindolinone derivative, and relates to the fields of natural products with biological activity and medicines. The raw materials are o-cyanobenzaldehyde derivatives, electron-rich aryl and diphenyl iodonium trifluoromethanesulfonate are used as raw materials, copper acetate is used as a catalyst, and the reaction is carried out in an o-dichloromethane solution at 110 ℃ to obtain the 3-aryl isoindolinone derivatives. The 3-aryl isoindolinone derivative can be obtained by reacting for 2-3 hours at 110 ℃ by using the method provided by the invention, and the yield is 69-99%. The reaction uses simple and easily obtained raw materials, and the 3-aryl isoindolinone derivative is synthesized by a one-pot method, so that a novel, simple, efficient and green synthesis method is provided for synthesizing the derivative. |
| priorityDate | 2017-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.