http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107382779-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-04 |
| filingDate | 2017-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107382779-B |
| titleOfInvention | Preparation method of shakubiqu intermediate |
| abstract | The invention discloses a synthetic method of a shakubiqu intermediate, belonging to the field of chemical pharmacy and comprising the following steps: the initial raw material glycine reacts with di-tert-butyl dicarbonate under the alkaline condition to carry out dehydrogenation and amino protection, and then the initial raw material glycine and the di-tert-butyl dicarbonate are substituted, deprotected and salified with a compound of a formula II under the action of a chiral catalyst by a one-pot method to obtain a chiral intermediate compound of a formula III. Reducing the compound shown in the formula III, refining to form salt to obtain the compound shown in the formula IV, and carrying out amino protection on the compound shown in the formula IV and di-tert-butyl dicarbonate to generate a target product (R) -tert-butyl (1- ([1,1' -biphenyl ] -4-yl) -3-hydroxypropane-2-yl) carbamate shown in the formula I. The synthesis method of the shakubiqu intermediate provided by the invention has the advantages of easily available raw materials and reagents, mild reaction conditions, high total yield, low cost, refining process of twice salification, simple post-treatment operation, reliable and stable product quality, and the whole process is very suitable for industrial production. |
| priorityDate | 2017-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.