http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107365302-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-96 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2016-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107365302-B |
| titleOfInvention | Spiro three-membered ring, spirofive-membered ring peptoid deformylase inhibitors |
| abstract | The invention discloses antibacterial activity and antitumor activity of a novel peptide deformylase inhibitor containing a spiro three-membered ring and a spiro five-membered ring. The spirocyclic peptoid deformylase inhibitor containing the spirotricyclic and the spiropentacyclic can be used as a novel antibacterial agent, is effective to various antibiotic-resistant gram-positive bacterial strains by inhibiting the activity of peptide deformylase required in the synthesis of bacterial protein, and does not influence the protein synthesis process of a human body, so that bacteria are selectively killed; the spirocyclic analog peptide deformylase inhibitor containing the spiro three-membered ring and the spiro five-membered ring can also be used as a novel anti-cancer drug, and can influence the energy balance of cells by inhibiting peptide deformylase in cancer cell mitochondria: thereby depolarizing mitochondrial membrane, depleting ATP and promoting apoptosis, and has good inhibitory activity on various cancer cell strains such as colorectal cancer, lung cancer, gastric cancer and liver cancer at low concentration. |
| priorityDate | 2016-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 612.