| abstract |
The invention provides a method for converting cyano into deuterated methyl by catalysis, an aromatic deuterated methyl compound prepared by the method and application of the aromatic deuterated methyl compound, wherein the method comprises the following steps: deuterium gas is used as a deuterium source, and an aromatic cyano compound is reacted under the action of a metal catalyst to generate an aromatic deuterated methyl compound. The method takes deuterium gas as a deuterium source, directly catalyzes a cyano group into a deuterated methyl group, has simple operation, cheap and easily obtained raw materials, high reaction yield and high deuteration rate of a product, and can be applied to large-scale production. The aromatic deuterated methyl compound prepared by the invention can be used as a deuterated drug or can be prepared into a deuterated drug or a deuterated drug composition, and the pharmacokinetics and pharmacodynamics of the drug can be improved or the metabolic toxicity of the drug can be reduced while the activity of drug molecules is kept basically unchanged. |