http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107337666-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2017-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107337666-B |
| titleOfInvention | It is a kind of for treating the preparation method of the lenalidomide of Huppert's disease |
| abstract | The present invention relates to be related to medicine synthesis technique, it discloses a kind of for treating the preparation method of Huppert's disease drug lenalidomide, wherein, the preparation method includes: 1) by 2- methyl-3-nitro methyl benzoate and 3- amino -2,6- piperidine dione carries out hybrid reaction in organic solvent in the presence of tetramethylethylenediamine and zinc bromide and obtains 3- (7- nitro -3- oxo -1H- iso-indoles -1- base) piperidines -2,6- diketone；2) 3- (7- amino -3- oxo -1H- iso-indoles -1- base) piperidine-2,6-diones are obtained into lenalidomide through catalytic hydrogen reduction.The preparation method of lenalidomide of the invention, mild condition, reaction step be simple and direct, it is environmentally friendly, be more suitable for industrialized production. |
| priorityDate | 2017-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.