http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107312765-B
Outgoing Links
Predicate | Object |
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 |
filingDate | 2017-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2020-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2020-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-107312765-B |
titleOfInvention | A kind of glycosaminoglycan lyase and its encoding gene and application |
abstract | The present invention relates to a glycosaminoglycan lyase that is difficult to degrade CS-E, its encoding gene and application. The amino acid sequence of the glycosaminoglycan lyase is shown in SEQ ID NO.2; the coding gene and nucleotide sequence of the glycosaminoglycan lyase are shown in SEQ ID NO.1; the glycosaminoglycan cleavage prepared by the present invention The specific activities of the enzymes to HA and CS-A, CS-C, CS-D, CS-E were 13.8, 7.2, 6.7, 5.9, 5.3 U/mg, respectively. And using low-sulfated CS-E polysaccharide as a substrate to prepare high-sulfated oligosaccharides with different degrees of polymerization, the prepared high-sulfated oligosaccharides can be used for anti-tumor metastasis. The enzyme can also be used in the fields of medicine and cosmetics, and has broad application prospects. |
priorityDate | 2017-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 581.