http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107303306-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-715 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-233 |
| filingDate | 2016-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107303306-B |
| titleOfInvention | Application of bupleurum or polysaccharide of processed product thereof as P multidrug resistance reversal agent |
| abstract | The invention discloses an application of bupleurum or polysaccharide of processed products thereof as a P glycoprotein multidrug resistance reversal agent, and in vitro experiments show that bupleurum polysaccharide can obviously increase the uptake of MRP2 substrate cisplatin in HEK293 cells with high expression of MRP2, and can also obviously increase the uptake of P glycoprotein substrate rhodamine B in HEK293 cells with high expression of P glycoprotein; safety research shows that the bupleurum polysaccharide is basically nontoxic and does not influence the proliferation of HEK293 cells, so that the bupleurum polysaccharide or polysaccharide of a processed product thereof can be used for preparing medicines for inhibiting the activity of multidrug resistance protein-related protein 2 and P glycoprotein. The invention has the beneficial effects that: the sensitivity of the chemotherapy drugs to cancer cells is enhanced, the curative effect of the drugs is enhanced, the bupleurum polysaccharide is safe and non-toxic, and is expected to be developed into a tumor MDR reversal agent. |
| priorityDate | 2016-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.