http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107298679-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2017-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107298679-B |
| titleOfInvention | A kind of synthetic method of chloro- 1H- pyrrolo- [2,3-B] pyridine -4- amine of 5- |
| abstract | The present invention relates to a kind of synthetic methods of chloro- 1H- pyrrolo- [2,3-B] pyridine -4- amine of 5-.Mainly solve the technical issues of wantage is combined to method.Synthetic method of the present invention generates compound 1 the following steps are included: the chloro- 7- azaindole of 4- reacts in tetrahydrofuran with sodium hydride, tri isopropyl chlorosilane at room temperature；Compound 1 is in tetrahydrofuran and s-butyl lithium, carbon trichloride low-temp reaction generate compound 2；Compound 2 and sodium azide, ammonium chloride react under n,N-Dimethylformamide high temperature, generate compound 3；Under palladium carbon catalytic action, compound 3 by hydrogenated at normal pressure, generates target compound 4 in ethanol.As expensive fine chemical product, chloro- 1H- pyrrolo- [2, the 3-B] pyridine -4- amine of 5- is used widely in pharmaceutical industry. |
| priorityDate | 2017-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.