| abstract |
The present invention relates to compounds of formula I for use as inhibitors of PARG (poly ADP-ribose sugar hydrolase) enzymatic activity: wherein R 1a , R 1b , R 1c , R 1d , R 1e , W, X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , c are as defined herein above. The invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions containing them, and to their use in the treatment of proliferative diseases such as cancer and other diseases or conditions in which PARG activity is implicated. |