http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107286212-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2016-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107286212-B |
| titleOfInvention | Preparation method of high-purity didanosine impurity |
| abstract | The invention discloses a preparation method of high-purity didanosine impurities, which is characterized by easy acquisition of adopted reagents, simple synthesis operation, mild reaction conditions and high product purity. Which comprises the following steps: 1) taking 2-acetoxy isobutyryl chloride and inosine as initial raw materials, and carrying out bromination reaction and acylation reaction in a solvent under the catalysis of lithium bromide; 2) concentrating the reaction solution obtained in the step 1, removing the solvent, and dissolving the reaction solution in a polar solvent to be directly used in the next step; 3) adding an alkaline reagent into the mixture at low temperature, adjusting the pH value to be in a strong alkali condition, and reacting to obtain the 2 ', 3' -anhydroinosine. |
| priorityDate | 2016-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.