| abstract |
The present invention relates to class phenyl [a] indoles [2,3-g] and quinolizine class compound, its preparation method, pharmaceutical composition and its application.Specifically, the present invention relates to phenyl [a] indoles [2 shown in the novel below formula (Ι) of a class formation, 3-g] and quinolizine class compound and derivative, its preparation method, pharmaceutical composition and its application in the metabolic disease medicines such as the treatment disease related to proprotein convertase subtilisin Kexin-9 types (PCSK9), including prevention and treatment hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, fatty liver deformation, atherosclerosis, obesity are prepared.Compound disclosed herein can also reduce T-CHOL, LDL- cholesterol and triglycerides, and increase liver ldl receptor expression, suppress PCSK9 expression and the protein kinase of activation AMP activation. |