abstract |
The present invention relates to one kind 2,4- disubstituted pyrimidines derivative and its as the application for treating upper effective Cyclin dependent kinase (CDK) inhibitor.Specifically, the present invention relates to 2,4- disubstituted pyrimidines derivative new shown in a kind of logical formula (I) and its pharmaceutical compositions, it is alternatively that property CDK4/6 inhibitor is preventing or treating and the purposes in CDK4/6 related disease. |