http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107286101-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
filingDate | 2017-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2020-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2020-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-107286101-B |
titleOfInvention | 1-aryl aldoxime uracil and its preparation method |
abstract | A1-aryl aldoxime uracil and a preparation method thereof relate to the field of medicines, in particular to a 1-aryl aldoxime uracil which can inhibit the growth activity of tumor cells and has obvious inhibition thymidine phosphorylase and anti-tumor activity and a preparation method thereof. The 1-aryl aldoxime uracil of the present invention is characterized in that the compound has the following structure I: wherein R is 1 Is methyl or hydrogen, R 2 Is chlorine, iodine, carboxyl or hydrogen, Ar is alkyl phenyl, halogenated phenyl, alkoxy phenyl, thienyl or furyl. The 1-aryl aldoxime uracil and the preparation method thereof show high activity of inhibiting the growth of tumor cells, have the functions of obviously inhibiting thymidine phosphorylase and resisting tumor activity, have simple and convenient preparation process and high feasibility, are convenient for large-scale production, and are beneficial to reducing the production cost. |
priorityDate | 2017-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 407.