http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107286092-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-26 |
| filingDate | 2017-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107286092-B |
| titleOfInvention | Method for preparing isoquinoline diketone by carbon-hydrogen functionalization of methoxybenzamide and diazo ester |
| abstract | The invention discloses a method for preparing 4-ester-isoquinoline-1, 3-diketone by carbon-hydrogen functionalization of N-methoxybenzamide and diazo malonate, which comprises the following steps: 1) under the protection of inert gas, substituted N-methoxy benzamide and diazo malonate are used as substrates in a solvent, and [ RhCp Cl ] is used as a carrier 2 ] 2 /AgSbF 6 As a catalyst, acetic acid is used as an additive to carry out reaction; the reaction temperature is 100 plus or minus 5 ℃, and the reaction time is 12 plus or minus 1 hour; 2) cooling the reactant obtained in the step 1) to room temperature, concentrating, purifying the residue by column chromatography, wherein the eluent of the column chromatography is petroleum ether: and (3) ethyl acetate is 30-1: 1 volume ratio of the mixed solution to obtain the 4-ester-isoquinoline-1, 3-diketone compound. |
| priorityDate | 2017-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.