| abstract |
The present invention relates to a kind of synthetic method of colchicin.The synthetic method of the colchicin by using For raw material, key reaction is used as with reference to efficient intramolecular [5+2] cycloaddition, the reaction of the dehydrogenation last of the twelve Earthly Branches gram and fertile gram of reaction are oriented to reference to seeking group, rapidly construct the skeleton structure of molecule, it is colchicin so as to obtain with Structures of Natural Products identical structural formula, people are conducive to carry out modification research to colchicin, to improve the bioactivity and toxic side effect of colchicin. |