| abstract |
The invention discloses a kind of design and application based on the double delivery systmes of hydrogen peroxide, the medicine of light stimulus and fluorescence, it is response group using hydrogen peroxide as the target molecule of insoluble drug release, borate, design has synthesized the double delivery systmes of the medicine and fluorescence of hydrogen peroxide and light stimulus.By determining prodrug (CM 1) fluorescence property, it is found that prodrug (CM 1) can respond hydrogen peroxide release fluorescence well；Meanwhile, compared to other photosensitizers, prodrug has more preferable stability and targeting；Its antitumor activity is determined using mtt assay, it is found that compound (CM 1) has the antitumor activity higher than Chlorambucil, illustrates that the targeting of compound (CM 1) is higher than Chlorambucil；According to the fluorescent characteristic of cumarin, intake situation of the cell to medicine is probed into, test result indicates that prodrug can be by cellular uptake.A kind of effective research tool is provided for the release of medicine in cell research. |