http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107266356-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-572 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-572 |
| filingDate | 2017-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107266356-B |
| titleOfInvention | Carbazole compound serving as autotaxin inhibitor and preparation method and application thereof |
| abstract | The invention belongs to the technical field of biological pharmacy, and aims to provide a carbazole compound serving as an autotaxin inhibitor, provide application of the carbazole compound in preparing a medicament for targeted inhibition of autotaxin activity, prepare an application in preparing a medicament for treating and preventing diseases or symptoms caused by increase of lysophosphatidic acid and autotaxin, and prepare an anti-tumor medicament. The compound is a2, 7-substituted carbazole derivative, specifically 5- [7- (4-R2-benzyloxy) -9H-carbazole-2 methylene ] -2-R1 phenol, R1-SWS-R2 for short; r1 is methyl or ethyl; r2 is any one of halogen, boric acid, sulfonyl, phosphate, carboxyl and amino acid. The compound has good anti-tumor activity on autocrine high-expression cell strains, and has no obvious influence on low-expression cell strains. Can prepare corresponding antitumor drugs and provide possibility for designing novel autotaxin inhibitors. |
| priorityDate | 2017-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 175.