| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0034
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y105-03001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y305-0201
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y305-03003 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-86 |
| filingDate |
2016-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2022-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-107257855-B |
| titleOfInvention |
modified creatinase |
| abstract |
The present invention relates to mutant polypeptides having creatine amidinohydrolase activity, wherein the polypeptides retain thermostable activity in the presence of agents that modify thiol groups. The present invention also relates to a method for producing the mutant polypeptide; and to the use of a sensor comprising the mutant polypeptide for measuring creatinine in a sample of physiological fluid. In addition, the present invention teaches how to use mutant polypeptides to increase the lifetime of creatinine sensors, as well as methods of making the sensors. |
| priorityDate |
2015-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |