http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107253986-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70557 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate | 2017-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107253986-B |
| titleOfInvention | Use of integrin intracellular polypeptide sequence in inhibiting neovascularization |
| abstract | The invention relates to a series of polypeptide compounds which contain an integrin conserved sequence and have the function of blocking the formation of new vessels in vivo and in vitro. The functional polypeptide compound is the amino acid sequence shown in the first claim. The small molecular polypeptide compounds can enter cells through coupling with cell-penetrating polypeptides, and further block the formation of new blood vessels by combining common signal protein molecules, have the effect of inhibiting the growth of solid tumors in experimental mice, and belong to the field of biomedicine. The invention can inhibit the formation of vascular structures of human umbilical vein endothelial cells in vitro, inhibit the generation of blood vessels in the subcutaneous inoculation matrix glue of the nude mice and inhibit the growth of subcutaneous inoculation solid tumors of the nude mice based on the functional small molecule polypeptide compound and the effector protein molecule thereof. The research finds that not only a plurality of lead compounds with the function of resisting the formation of new blood vessels are provided, but also a new mechanism for regulating the formation of new blood vessels is disclosed, so that a new target site is provided for developing a new generation of anti-new blood vessel formation and anti-tumor drugs. |
| priorityDate | 2017-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.