| abstract |
The present invention relates to substituted bicyclic dihydropyrimidinones of formula 1, and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing them, and their use as medicaments for treatment and/or prevention Methods of pulmonary, gastrointestinal and genitourinary diseases, inflammation of the skin and eyes, and other autoimmune and allergic disorders, allograft rejection, and neoplastic diseases. |