| abstract |
The invention relates to a hydroxylation method of halogenated aromatic compounds, which takes 2-pyridone compounds as ligand additives and CuI as catalysts, can realize the hydroxylation reaction of MOH and halogenated aromatic compounds under mild conditions in the presence of phase transfer catalysts and solvents, and has high reaction yield and wide substrate application range. Compared with the same type of reaction reported in the literature, the method has the advantages of mild reaction conditions, high yield and good application prospect. The hydroxylation reaction of the iodo aromatic compound can be carried out in aqueous solution at 90 ℃ and obtains a high yield of hydroxylated products, and the reaction temperature can be reduced by about 30 ℃ compared with the report in the literature on average; hydroxylation of aromatic bromide in aqueous solution can be carried out at 120 deg.C, and the reaction temperature can be reduced by about 20 deg.C compared with the report in the literature. |