| abstract |
The invention provides a compound of formula I: Pharmaceutical compositions comprising these compounds, and methods of using these compounds to treat or prevent diseases or conditions mediated by FXR and/or TGR5. In certain embodiments, the disease involving modulation of the TGR5 receptor is selected from metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, renal disease, cancer, and gastrointestinal disease. |