http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107243000-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 |
| filingDate | 2017-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107243000-B |
| titleOfInvention | Drug-loaded hybrid nanoparticles and preparation method thereof |
| abstract | The invention discloses a drug-loaded hybrid nano particle, and a preparation method thereof comprises the following steps: (1) preparing a triazo-ketal compound; (2) preparing propargylamine modified heparin sodium; (3) propargylamine-modified heparin sodium-grafted azido triketal compound; (4) and (3) preparation of drug-loaded hybrid nano particles. The natural polymer heparin is used as the framework material of the nano particles, the heparin has good biological safety, and the drug-loaded hybrid nano particles prepared by a specific preparation process have the particle size within the EPR effect range, can realize passive targeting, have responsiveness in an overheat environment and can realize high-selectivity rapid drug release in tumor cells, so the prepared drug-loaded hybrid nano particles have the characteristics of good biocompatibility, high safety, no toxic or side effect and the like. |
| priorityDate | 2017-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 85.