http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107235969-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2017-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107235969-B |
| titleOfInvention | Key intermediate for synthesizing hexahydropyridine-2, 3-indole-2-ketone framework compound and preparation method and application thereof |
| abstract | The invention discloses a key intermediate of a piperidine-2, 3-indole-2-ketone skeleton compound, a preparation method and application thereof, wherein the key intermediate is prepared by carrying out Michael addition reaction on corresponding 3-monosubstituted oxindole 1 and nitroisoxazole alkene 2 under the condition of alkaline catalysis to generate a product 3. The piperidine derivative is a key intermediate for synthesizing a piperidine-2, 3-indoline-2-ketone framework compound, and the piperidine-2, 3-indoline-2-ketone framework compound has important application value in the drug screening and pharmaceutical industry. The method has the advantages of simple and easy operation, cheap and easily obtained raw material synthesis, capability of being carried out in various organic solvents, better air stability, wide applicability and good compatibility for various substituent groups. |
| priorityDate | 2017-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.