http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107235945-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-643 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-16 |
| filingDate | 2017-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107235945-B |
| titleOfInvention | A light-sensitive targeted anti-tumor prodrug that responds to glutathione to kill tumor cells and its preparation method and application |
| abstract | The invention discloses the design and application of a glutathione-, light-stimulated drug and fluorescence dual-release system. Glutathione is used as a target molecule for drug release and 2,4-dinitrosulfonyl chloride is used as a response group Group, designed and synthesized glutathione and photostimulated drug and fluorescence dual-release system. By measuring the fluorescence properties of the prodrug (CM-2), it was found that the prodrug (CM-2) could respond well to glutathione to release fluorescence; at the same time, compared with other light-sensitive drugs, the prodrug had better stability The anti-tumor activity of the compound (CM-2) was higher than that of chlorambucil, indicating that the targeting of the compound (CM-2) was higher than that of chlorambucil. Nitrogen mustard was higher; according to the fluorescence characteristics of coumarin, the uptake of the drug by cells was explored, and the experimental results showed that the prodrug could be taken up by cells. It provides an effective research tool for drug release in cell research. |
| priorityDate | 2017-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.