http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107235921-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 |
| filingDate | 2017-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107235921-B |
| titleOfInvention | A kind of preparation method of Erlotinib |
| abstract | The present invention relates to a kind of preparation methods of Erlotinib.The method of synthesis Erlotinib of the present invention, includes the following steps: (1) compound 1 reacts under conditions of catalytic amount boron trifluoride ether with paraformaldehyde generates compound 2；(2) compound 2 reacts under catalytic amount tetrabutylammonium bromide and ultrasound condition with ammonium hydroxide generates compound 3；(3) compound 3 is reacted with thionyl chloride generates compound 4；(4) compound 4 is reacted with 3-aminophenylacetylene generates Erlotinib. |
| priorityDate | 2017-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.