| abstract |
The invention belongs to the field of synthetic pharmaceutical chemistry, and relates to diaryl-beta-lactam compounds with a general formula structure and obvious anti-tumor activity and application thereof in pharmacy. The invention also comprises the application of the compound, the medicinal salt and the medicinal composition thereof in preparing medicaments for preventing or treating diseases related to tumors. The compound or the pharmaceutically acceptable salt thereof provided by the invention can inhibit the growth of tumor cells in vitro and in vivo by inhibiting the tubulin aggregation through a regulation mechanism for inhibiting the growth of the tumor cells, and can be applied to the preparation of medicaments for preventing or treating tumor-related diseases; the tumor-related diseases include benign and malignant tumors and other diseases caused by tumors. |