http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107226858-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-555 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-58 |
| filingDate | 2016-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107226858-B |
| titleOfInvention | Preparation and application of interferon high-molecular conjugate IFN-PMPC |
| abstract | The invention discloses a preparation method and application of an interferon polymer conjugate IFN-PMPC. The invention provides a method for preparing a protein-macromolecule combination, which comprises the following steps: mixing protein-initiator combination, 2-methacryloyloxyethyl phosphorylcholine, CuCl 2 Carrying out polymerization reaction on 1,1,4,7,10, 10-hexamethyl triethylene tetramine in a buffer solution to obtain a protein-polymer combination; the protein-initiator combination is a product obtained by covalently connecting an initiator and protein. Experiments prove that the IFN-PMPC combination prepared by the invention has high yield, simple purification, site-specific modification and no immunogenicity, can better retain in-vitro biological activity, greatly improves the pharmacokinetics and biological distribution and effectively enhances the treatment effect. |
| priorityDate | 2016-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 185.