| abstract |
The invention belongs to the technical field of medicine, and specifically relates to tankyrase inhibitors represented by general formula (I), pharmaceutically acceptable salts, esters, solvates or stereoisomers thereof, wherein R 1 , R 2 , X 1 , X 2 , Y 1 , Y 2 , Y 3 , Y 4 , Z, L, n and A are as defined in the specification. The present invention also relates to the preparation method of these compounds, the pharmaceutical preparations and pharmaceutical compositions containing these compounds, and the compounds, their pharmaceutically acceptable salts, esters, solvates or their stereoisomers in the preparation of therapeutic and/or prophylactic Drug application in cancer and related diseases mediated by tankyrase. |