http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107216297-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-82 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-82 |
| filingDate | 2017-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107216297-B |
| titleOfInvention | Asymmetric synthesis method of chiral dihydrofuran compound |
| abstract | The invention provides an asymmetric synthesis method of chiral dihydrofuran compounds shown as a formula (I), which comprises the following steps: mixing 1, 3-cyclohexanedione compounds shown in formula (II), nitroolefin compounds shown in formula (III), chiral squaric acid catalyst and organic solvent ACompletely reacting at-20-60 ℃ to obtain a compound shown in a formula (IV), adding an iodine source additive, an alkaline substance and an organic solvent B into the compound shown in the formula (IV), completely reacting at-20-60 ℃, and carrying out post-treatment on a reaction solution to obtain a chiral dihydrofuran compound shown in the formula (I); the method has the advantages of mild reaction conditions, high product yield and excellent selectivity; the prepared chiral dihydrofuran compound has chirality and novel core skeleton structure. |
| priorityDate | 2017-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 140.