http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107213176-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-333 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-185 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K127-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-185 |
| filingDate | 2017-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107213176-B |
| titleOfInvention | Hydrangea macrophylla leaf extract, and pharmaceutical composition, preparation method and application thereof |
| abstract | The invention belongs to the field of traditional Chinese medicine and natural medicine pharmacy, and relates to a hydrangea macrophylla leaf extract, a pharmaceutical composition, a preparation method and application thereof. The invention aims to provide application of total phenolic acid extracts of hydrangea macrophylla leaves in preparation of medicines for treating thyroid cancer. The preparation method of the hydrangea leaf extract comprises the following steps: (1) pulverizing flos Impatientis leaf, and extracting with solvent; (2) filtering, and concentrating the filtrate for later use; (3) extracting the concentrated solution to obtain extract, adding water into the extract, and filtering to obtain filtrate; (4) adsorbing the filtrate with macroporous resin column, sequentially eluting with distilled water, 10-20% ethanol water solution, 20-30% ethanol, and 30-40% ethanol, collecting 30-40% ethanol eluate, concentrating, drying, pulverizing, and sieving to obtain hydrangea macrophylla leaf extract. The content of the total phenolic acid in the total phenolic acid extract of the hydrangea macrophylla leaves is up to 40 percent, and the quality is stable and controllable. The extract has definite therapeutic effect on thyroid cancer through in vivo and in vitro pharmacological tests on thyroid cancer. |
| priorityDate | 2017-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.