| abstract |
The present invention relates to novel substituted bridged urea analogs of compounds of formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, methods of preparing the compounds, and the compounds alone or in combination with other therapeutic agents as Use of sirtuin modulators in increasing cellular lifespan, treating and/or preventing a wide range of diseases and conditions including, but not limited to, for example, diseases or conditions associated with aging or stress, diabetes, Obesity, neurodegenerative disease, cardiovascular disease, coagulation disorders, inflammation, cancer and/or flushing and diseases or conditions that would benefit from increased mitochondrial activity. |