| abstract |
The present invention provides a pyrrole compound, which is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrole-2-yl)-N-(4-(4-(5- Fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or its deuterated derivatives, or (b) 2-(1,5-dimethyl-3-phenyl -1H-pyrrole-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or Its deuterated derivative, or (c) a precursor of compound (a) or a precursor of compound (b), or a pharmaceutically acceptable salt of (a), (b) or (c) or an agriculturally acceptable of salt. Combinations and compositions comprising the compounds and known antifungal agents are also provided. The invention also relates to the therapeutic use of the compounds according to the invention in the treatment and prophylaxis of fungal diseases. It involves 2‑(1,5‑dimethyl‑3‑phenyl‑1H‑pyrrol‑2‑yl)‑N‑(4‑(4‑(5‑fluoropyrimidin‑2‑yl)piperazine‑1‑ yl)phenyl)-2-oxoacetamide or an agriculturally acceptable salt thereof, or 2-(1,5-dimethyl-3-phenyl-1H-pyrrole-2-yl)-N-( 4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or an agriculturally acceptable salt thereof as an antifungal agent in agriculture use. |