http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107206085-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-401 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-401 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate | 2015-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107206085-B |
| titleOfInvention | Using alpha9Migration and release of HSCs for integrin antagonists and CXCR4 antagonists |
| abstract | Hematopoietic stem cell mobilization is a process by which hematopoietic stem cells stimulate the bone marrow space, and before HSCs can be mobilized, they must be mobilized and released from the BM stem cell niche where they reside and are retained by adhesive interactions. Thus, in one aspect of the invention, there is provided a method for enhancing the migration of HSCs and their precursors and progenitors thereof from a BM stem cell binding ligand in vivo or ex vivo, the method comprising administering an effective amount of an alpha to the BM stem cell niche in vivo or ex vivo 9 An antagonist of an integrin or active portion thereof and a CXCR4 antagonist or active portion thereof. Once mobilized to Peripheral Blood (PB), HSCs can be collected for transplantation. Methods of enhancing HSC mobilization can also improve treatment of hematological disorders. |
| priorityDate | 2014-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 395.