http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107200753-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 |
| filingDate | 2017-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107200753-B |
| titleOfInvention | A kind of preparation method of methotrexate (MTX) and Allan sodium phosphate conjugate |
| abstract | A kind of preparation method of methotrexate (MTX) and Allan sodium phosphate conjugate, the invention belongs to organic pharmaceutical manufacturing technical fields.Methotrexate (MTX), ultrapure water, organic solvent are mixed, methotrexate (MTX) solution is obtained；Again by morpholino b acid, N- hydroxysuccinimide, 1-(3- dimethylamino) -3- ethyl-carbodiimide hydrochloride is added in above-mentioned methotrexate (MTX) solution, obtain methotrexate (MTX) mixed solution；Under magnetic stirring, methotrexate (MTX) mixed solution is mixed with Alendronate sodium and is reacted, after dialysing, freeze-drying obtains nanoscale methotrexate (MTX) and Allan sodium phosphate conjugate.This conjugate can obtain a kind of novel orthopaedics targeted drug, drug is enriched with to orthopaedics disease Zhao position, to reach better therapeutic effect. |
| priorityDate | 2017-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.