http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107184617-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 |
| filingDate | 2017-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107184617-B |
| titleOfInvention | Application of ginkgolic acid in preparation of product for preventing and/or treating allergic diseases |
| abstract | The invention discloses a traditional Chinese medicine active compound with Syk inhibitory activity, and a preparation method and application thereof. The invention finds that the active compound ginkgolic acid C15:1 or ginkgolic acid C13:0 has spleen tyrosine kinase (Syk) inhibitory activity, further researches show that the active compound also has the effect of inhibiting mast cell degranulation, and the traditional Chinese medicine active compound ginkgolic acid C15:1 is obtained from ginkgo medicinal materials for the first time, and is verified to have the Syk inhibitory activity and the mast cell degranulation inhibitory activity. The active compound ginkgolic acid C15:1 or ginkgolic acid C13:0 has simple effective components and chemical components and definite action targets, can directly inhibit Syk activity and inhibit mast cell degranulation, is easier to clarify the action mechanism in pharmacological research, has potential application value in the aspect of preventing and treating allergic asthma, and provides new drug selection for preventing and treating allergic asthma. |
| priorityDate | 2017-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.