http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107176970-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f80261800586b082031a36b06557c670 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06078 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-065 |
| filingDate | 2017-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d98bf9388e7303b6d6c0cf69676e078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a4ede07fd4d81046aad928cf82e25ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be2d411c8a4396e0609b2186068bd7dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2af3cd5e53f291f1594d569fb5519c10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0967b39ec65ca87cff6209c895d8304 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32cf2343d7a2306b6853623a3ef5edae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bab1ab419142edb79dc92ad4cb2630ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64dcf54ad4e027f1b4fd93c6cc780fa7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acae17e54151476a6f822f996ec0bbdc |
| publicationDate | 2017-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107176970-A |
| titleOfInvention | A method for synthesizing pseudoproline heterocyclic peptides by resin catalysis |
| abstract | The invention provides a method for synthesizing pseudo-proline heterocyclic peptides by a resin catalysis method, which belongs to the technical field of peptide synthesis. The method comprises the following steps: (1) reacting the amino acid protected by Fmoc with one of serine, threonine or cysteine to generate a dipeptide; (2) reacting the dipeptide obtained in step (1) Condensation reaction with 2,2-dimethoxypropane under the catalysis of acidic resin, the obtained product is filtered to remove the acidic resin, and then concentrated and separated to obtain the target product pseudo-proline heterocyclic peptide. The method for synthesizing pseudoproline heterocyclic peptides provided by the present invention does not require repeated salt formation and desalination, and the purification of the product does not require repeated column chromatography. The yield of the final product can reach 90%, and the purity can reach 97%. The method has the characteristics of simple reaction operation, high reaction yield, low product impurity content, low preparation cost and the like, and can adapt to industrialized production. The structure of the pseudoproline heterocyclic peptide is shown as: |
| priorityDate | 2017-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.