http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107176965-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J43-003 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 |
| filingDate | 2016-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107176965-B |
| titleOfInvention | Novel method for synthesizing abiraterone acetate |
| abstract | The invention relates to a novel method for synthesizing abiraterone acetate, belongs to the field of medicine synthesis, and particularly relates to a novel method for synthesizing abiraterone acetate serving as a medicine for treating advanced prostate cancer and a preparation method of a novel intermediate compound involved in the synthesis method. The invention adopts dehydropregnenolone acetate as a raw material, and the target compound abiraterone acetate is synthesized by the reaction of oxidation, hybrid D-A, isomerization, acetylation and the like of the propenol 3 through the addition and rearrangement reaction of methyl R-based sulfoxide lithium reagent to obtain the propenol product 3. The invention solves the problem of expensive synthesis raw materials in the prior art, provides a method for preparing abiraterone and abiraterone acetate, which has the advantages of high yield, small environmental pollution and simple and convenient purification, and is easy to be amplified to industrial production. |
| priorityDate | 2016-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.