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filingDate 2017-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-107158378-B
titleOfInvention Copper-manganese sulfide protein composite nanoparticle for photothermal effect and preparation method thereof
abstract The invention belongs to the field of preparation of photothermal treatment nano composite materials, and particularly relates to a copper sulfide manganese protein composite nano material for photothermal effect and a preparation method thereof. Taking dark green citrate-coated copper sulfide nanocrystal solution as raw material, and adding divalent manganese ions (Mn) 2+ ) And assembling dipyridyl methyl amine (PDA) substituted by boron fluorine pyrrole with the surface of the nano copper sulfide nano crystal, and then applying a method of coating Bovine Serum Albumin (BSA) modified by PEG-FA-COOH to successfully synthesize the novel copper manganese sulfide protein composite nano particle with higher photo-thermal conversion efficiency. The inorganic nano photothermal reagent prepared by the method can be used for multifunctional tumor diagnosis and treatment, can solve the problem of low photothermal effect in tumor photothermal treatment, and is a photothermal diagnosis and treatment agent guided by multifunctional magnetic resonance imaging and light-excited cell fluorescence imaging with low toxicity, biocompatibility and tumor targeting.
priorityDate 2017-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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