| abstract |
The present invention discloses a class of glycopeptide antibiotic derivatives represented by the general formula (I) and pharmaceutically acceptable salts thereof and a preparation method thereof, wherein R is a substituted or unsubstituted benzene ring or a biphenyl ring, The substituents of the substituted benzene ring and biphenyl ring are one or more halogens, hydroxyl groups, amino groups, C 1 -C 9 alkoxy groups, nitro groups, or isopropyl groups; R 2 is H. In addition, the present invention also provides pharmaceutical compositions containing the glycopeptide antibiotic derivatives and pharmaceutically acceptable salts thereof as active ingredients and applications thereof. The compounds and pharmaceutical compositions provided by the invention have good antibacterial activity and are of great significance for the development of new antibacterial drugs. |