http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107144648-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| filingDate | 2017-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107144648-B |
| titleOfInvention | Detect the liquid chromatography-tandem mass spectrometry method of Pitavastatin in human plasma |
| abstract | The present invention relates to the liquid chromatography-tandem mass spectrometry methods of Pitavastatin in detection human plasma.The present invention provides the methods of Pitavastatin concentration in detection blood plasma, are analyzed by LC-MS/MS Pitavastatin concentration in blood plasma.The method of the present invention preferably uses albumen precipitation preprocess method, using deuterated Pitavastatin as internal standard, using Eclipse Plus Phenyl-Hexyl column isocratic elution, the detection of electrospray ionisation source (ESI) tandem mass spectrum.The plasma sample extraction recovery of the method for the present invention is set to be greater than 93%, it is not influenced by matrix effect, Pitavastatin stability is investigated using statistics Pitavastatin concentration RSD% before pretreatment, guarantee the accuracy of determination data, its specificity selectivity is strong, high sensitivity, detection is quick, dosage is small, meets simple, reliable, the clinical batch samples of high-throughput, condition controllably and analyzes demand.Specificity, stability of the method for the present invention etc. are verified, and the bioequivalence of evaluation each dosage form of Pitavastatin is successfully used for. |
| priorityDate | 2017-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.