http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107141279-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-22 |
| filingDate | 2017-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107141279-B |
| titleOfInvention | A kind of preparation method of 3- (thiophene -2- base) hexamethylene -2- ketenes derivative |
| abstract | The present invention relates to thiophene derivant preparation method technical fields, and in particular to a kind of preparation method of 3- (thiophene -2- base) hexamethylene -2- ketenes derivative.A kind of preparation method of 3- (thiophene -2- base) hexamethylene -2- ketenes derivative of the present invention, include the following steps: (1) in the reactor, 3:1:0.1:2.5:0.1:0.2 sequentially adds cyclonene, thiophene or substituted thiophene, palladium chloride, silver carbonate, N- acetoglycocoll and silver hexafluoroantimonate in molar ratio, solvent is added to dissolve reactant, it is uniformly mixed, is then reacted 5~48 hours under the conditions of 60~120 DEG C at room temperature；(2) reactor is cooled to room temperature after the reaction was completed, is dissolved with ethyl acetate, successively washed with saturated ammonium chloride and saturated sodium-chloride water solution, after organic phase is dried over anhydrous sodium sulfate, filtering, solvent is removed in rotation on a rotary evaporator；(3) rotation is gone to the residue silica gel column chromatography separating purification after solvent, target product is collected, rotates away solvent, oil pump is drained. |
| priorityDate | 2017-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.