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filingDate 2017-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2019-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-107137788-B
titleOfInvention A method for preparing chitosan/heparinized graphene oxide composite multilayer film on the surface of medical magnesium alloy
abstract The invention discloses a method for preparing a chitosan/heparinized graphene oxide composite multilayer film on the surface of a medical magnesium alloy. First, negatively charged heparinized graphene oxide is prepared, and then the medical magnesium alloy is subjected to surface chemical treatment. Self-assembled 16-phosphonohexadecanoic acid molecules, further covalently immobilized chitosan on the surface of magnesium alloys, thereby constructing a positively charged material surface, and finally the surface-modified magnesium alloy materials were alternately immersed into heparinized graphene oxide The chitosan/heparinized graphene oxide composite multi-layer film is obtained after being fully adsorbed in the chitosan solution. Using the method of the invention to modify the surface of the medical magnesium alloy can significantly improve the corrosion resistance and biocompatibility of the magnesium alloy, and lay a foundation for the application of the magnesium alloy in the field of implantable medical devices such as vascular stents.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110327484-A
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type http://data.epo.org/linked-data/def/patent/Publication

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