http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107130000-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 |
| filingDate | 2017-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107130000-B |
| titleOfInvention | CRISPR-Cas9 system for simultaneously knocking out KRAS gene and EGFR gene and application thereof |
| abstract | The invention discloses a CRISPR-Cas9 system for simultaneously knocking out KRAS gene and EGFR gene, which comprises sgRNA of a specific target KRAS gene, corresponding DNA sequences of which are shown as SEQ ID No.1 or/and SEQ ID No.2, and sgRNA of a specific target EGFR gene, and corresponding DNA sequences of which are shown as SEQ ID No.11 or/and SEQ ID No. 12. The invention also discloses application of the compound in preparing a medicament for treating cancer. The CRISPR-Cas9 system can simultaneously and efficiently knock out two cancer driving factors KRAS and EGFR which are highly expressed in lung cancer, is simple to operate and high in knocking efficiency, and is expected to be applied to treatment of the lung cancer. The system of the invention is applicable to various cancers with abnormal expression of EGFR and KRAS. |
| priorityDate | 2017-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.